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Article

Copy Number Losses Define Subgroups of Dedifferentiated Liposarcoma with Poor Prognosis and Genomic Instability

13 Jan 2012

Abstract excerpt

PURPOSE: Molecular events underlying progression of well-differentiated liposarcoma (WDLS) to dedifferentiated liposarcoma (DDLS) are poorly defined. This study sought to identify copy number alterations (CNA) associated with dedifferentiation of WDLS, with DDLS morphology, and with patient outcomes. EXPERIMENTAL DESIGN: Fifty-five WDLS and 52 DDLS were analyzed using Agilent 244K comparative genomic...

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PMID: 22241790
DOI: 10.1158/1078-0432.ccr-11-2820

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