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HDM2 Promotes NEDDylation of Hepatitis B Virus HBx To Enhance Its Stability and Function

8 Jun 2017

Abstract excerpt

ABSTRACT Hepatitis B virus (HBV)-encoded X protein (HBx) plays a critical role in HBV-related hepatocarcinoma development. In this study, we demonstrate that HBx is specifically modified by NEDD8. We found that E3 ligase HDM2 promotes NEDDylation of HBx to enhance HBx stability by preventing its ubiquitination-mediated degradation. Consistently, analysis of 160 hepatocellular carcinoma patient specimens indicated...

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PMID: 28592528
DOI: 10.1128/jvi.00340-17

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