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Integrative metabolomics and transcriptomics analysis reveals novel therapeutic vulnerabilities in lung cancer

8 Jun 2022

Abstract excerpt

BACKGROUND: Non-small cell lung cancer (NSCLC) comprises the majority (~85%) of all lung tumors, with lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) being the most frequently diagnosed histological subtypes. Multi-modal omics profiling has been carried out in NSCLC, but no studies have yet reported a unique metabolite-related gene signature and altered metabolic pathways associated with LUAD and...

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PMID: 35676822
DOI: 10.1002/cam4.4933

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