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Antiapoptotic potency of Bcl-2 proteins primarily relies on their stability, not binding selectivity

13 Mar 2014

Abstract excerpt

All 6 human prosurvival Bcl-2 proteins can drive cancer development and contribute to therapy resistance. However, their relative abilities to protect cells against cancer therapy were not examined previously. We report that Bcl-2, Bcl-xL, or Bcl-w consistently protected leukemic cells better than Bcl-B, Bfl-1, or Mcl-1 against a wide variety of anticancer regimens. Current thinking would attribute this to...

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PMID: 24622325
DOI: 10.1182/blood-2013-08-519470

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