Article
Roles of Two Major Alcohol Dehydrogenases, ADH1 (Class I) and ADH3 (Class III), in the Adaptive Enhancement of Alcohol Metabolism Induced by Chronic Alcohol Consumption in Mice.
Alcohol and alcoholism (Oxford, Oxfordshire) - 7 Feb 2020
Haseba Takeshi, Okuda Takahisa, Maruyama Motoyo, Akimoto Toshio, Duester Gregg, Ohno Youkichi
Abstract excerpt
AIMS: It is still unclear which enzymes contribute to the adaptive enhancement of alcohol metabolism by chronic alcohol consumption (CAC). ADH1 (Class I) has the lowest Km for ethanol and the highest sensitivity for 4-methylpyrazole (4MP) among ADH isozymes, while ADH3 (Class III) has the highest Km and the lowest sensitivity. We investigated how these two major ADHs relate to the adaptive enhancement of alcohol...
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