Article
Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human small intestine.
Alcoholism, clinical and experimental research - 1 Dec 2012
Chiang Chien-Ping, Wu Chew-Wun, Lee Shiao-Pieng, Ho Ji-Lin, Lee Shou-Lun, Nieh Shin, Yin Shih-Jiun
Abstract excerpt
BACKGROUND: Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are principal enzymes responsible for metabolism of ethanol (EtOH). Functional polymorphisms of ADH1B, ADH1C, and ALDH2 genes occur among racial populations. This study aimed to systematically determine the functional expressions and cellular localization of ADH and ALDH family members in human small bowel. METHODS: One hundred and...
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