Article
Effects of ADH1B and ALDH2 Genetic Polymorphisms on Alcohol Elimination Rates and Salivary Acetaldehyde Levels in Intoxicated Japanese Alcoholic Men.
Alcoholism, clinical and experimental research - 1 Jun 2016
Yokoyama Akira, Kamada Yoko, Imazeki Hiromi, Hayashi Emiko, Murata Shigenori, Kinoshita Kenji, Yokoyama Tetsuji, Kitagawa Yoshinori
Abstract excerpt
BACKGROUND: The genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2) are associated with the risk of alcoholism and upper aerodigestive tract cancer in alcoholics. Salivary ethanol (sEtOH) levels are well correlated with blood EtOH levels. METHODS: To study the effects of ADH1B and ALDH2 genotypes on the alcohol elimination rate (AER) and salivary acetaldehyde (sAcH)...
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