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Article

Metabolic pharmacokinetics of early chronic alcohol consumption mediated by liver alcohol dehydrogenases 1 and 3 in mice.

Journal of gastroenterology and hepatology - 1 Nov 2018

Okuda Takahisa, Haseba Takeshi, Katsuyama Midori, Maruyama Motoyo, Akimoto Toshio, Igarashi Tsutomu, Ohno Youkichi

Abstract excerpt

BACKGROUND AND AIM: Alcohol dehydrogenases (ADHs) 1 and 3 are responsible for systemic alcohol metabolism. The current study investigated the contribution of liver ADH1 and ADH3 to the metabolic pharmacokinetics of chronic alcohol consumption (CAC). METHODS: The 9-week-old male mice of different ADH genotypes (wild-type [WT], Adh1-/- , and Adh3-/- ) were administered with 10% ethanol solution for 1 month,...

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Identifiers

PMID: 29663519
DOI: 10.1111/jgh.14260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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