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Article

In vivo susceptibility to energy failure parkinsonism and LRRK2 kinase activity.

Neurobiology of disease - 1 Jan 2022

Novello Salvatore, Mercatelli Daniela, Albanese Federica, Domenicale Chiara, Brugnoli Alberto, D'Aversa Elisabetta, Vantaggiato Silvia, Dovero Sandra, Murtaj Valentina, Presotto Luca, Borgatti Monica, Shimshek Derya R, Bezard Erwan, Moresco Rosa Maria, Belloli Sara, Morari Michele

Abstract excerpt

The G2019S mutation of LRRK2 represents a risk factor for idiopathic Parkinson's disease. Here, we investigate whether LRRK2 kinase activity regulates susceptibility to the environmental toxin 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP). G2019S knock-in mice (bearing enhanced kinase activity) showed greater nigro-striatal degeneration compared to LRRK2 knock-out, LRRK2 kinase-dead and wild-type mice...

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Identifiers

PMID: 34871735
DOI: 10.1016/j.nbd.2021.105579

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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