Article
LRRK2 and GBA Variants Exert Distinct Influences on Parkinson's Disease-Specific Metabolic Networks.
Cerebral cortex (New York, N.Y. : 1991) - 14 May 2020
Schindlbeck Katharina A, Vo An, Nguyen Nha, Tang Chris C, Niethammer Martin, Dhawan Vijay, Brandt Vicky, Saunders-Pullman Rachel, Bressman Susan B, Eidelberg David
Abstract excerpt
The natural history of idiopathic Parkinson's disease (PD) varies considerably across patients. While PD is generally sporadic, there are known genetic influences: the two most common, mutations in the LRRK2 or GBA1 gene, are associated with slower and more aggressive progression, respectively. Here, we applied graph theory to metabolic brain imaging to understand the effects of genotype on the organization of...
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