Article

<i>BCKDK</i>rs14235 A allele is associated with milder motor impairment and altered network topology in Parkinson’s disease

2023-07-26

Abstract excerpt

<h4>Background</h4> A multitude of genetic variants confer a risk of Parkinson’s disease (PD), however, whether these risk variants affected the motor symptoms of PD patients remain largely elusive. The objective of this study is to investigate the effects of BCKDK rs14235 (G > A), a risk variant associated with PD risk, on the motor manifestations and brain networks of PD patients. <h4>Methods</h4> PD patients (n...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b02aad63-d38f-533e-98a3-4aca44d99e22
DOI: 10.1101/2023.07.20.23292985

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>BCKDK</i>rs14235 A allele is associated with milder motor impairment and altered network topology in Parkinson’s diseaseDOI 10.1101/2023.07.20.23292985Read

Parkinson’s disease-associated genetic variants synergistically shape brain networksSemantic proximity Read

Effects of<i>MAPT</i>rs17649553 on Structural Network Integrity and Verbal Memory in Parkinson’s DiseaseSemantic proximity Read

<i>BIN3</i>rs2280104 T allele is associated with excessive daytime sleepiness and altered network topology in Parkinson’s diseaseSemantic proximity Read

Altered structural-functional coupling in Parkinson’s diseaseSemantic proximity Read

Motor Functional Hierarchical Organization of Cerebrum and Its Underlying Genetic Architecture in Parkinson’s DiseaseSemantic proximity Read

Mitochondria-mitochondria interaction networks show altered topological patterns in Parkinson’s diseaseSemantic proximity Read

Individualized brain radiomics-based network tracks distinct subtypes and abnormal patterns in prodromal Parkinson’s diseaseSemantic proximity Read

The Protein-Protein Interaction Network of Hereditary Parkinsonism Genes Is a Hierarchical Scale-Free Network.Semantic proximity Read

Individualized functional connectivity markers associated with motor and mood symptoms of Parkinson’s diseaseSemantic proximity Read

Disrupted topological organization of resting-state functional brain networks in Parkinson's disease patients with glucocerebrosidase gene mutations.Semantic proximity Read

MAPT rs17649553 T allele is associated with better verbal memory and higher small-world properties in Parkinson's disease.Semantic proximity Read

Identifying a Whole-brain Connectome-based Model in Drug-naïve Parkinson’s Disease for Predicting Motor ImpairmentSemantic proximity Read