Article
Mutant p53R273H attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species.
Journal of cell science - 15 Nov 2012
Kalo Eyal, Kogan-Sakin Ira, Solomon Hilla, Bar-Nathan Elad, Shay Moshe, Shetzer Yoav, Dekel Elya, Goldfinger Naomi, Buganim Yossi, Stambolsky Perry, Goldstein Ido, Madar Shalom, Rotter Varda
Abstract excerpt
Uncontrolled accumulation of reactive oxygen species (ROS) causes oxidative stress and induces harmful effects. Both high ROS levels and p53 mutations are frequent in human cancer. Mutant p53 forms are known to actively promote malignant growth. However, no mechanistic details are known about the contribution of mutant p53 to excessive ROS accumulation in cancer cells. Herein, we examine the effect of p53(R273H),...
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