Article
The role of tumor suppressor p53 in the antioxidant defense and metabolism.
Sub-cellular biochemistry - 1 Jan 2014
Budanov Andrei V
Abstract excerpt
Tumor suppressor p53 is inactivated in most cancers and the critical role of p53 in the suppression of carcinogenesis has been confirmed in many mouse models. The protein product of the tumor suppressor p53 gene works as a transcriptional regulator, activating expression of numerous genes involved in cell death, cell cycle arrest, senescence, DNA-repair and many other processes. In spite of the multiple efforts...
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