Article
Haplotypes of the HRES-1 endogenous retrovirus are associated with development and disease manifestations of systemic lupus erythematosus.
Arthritis and rheumatism - 1 Feb 2008
Pullmann Rudolf, Bonilla Eduardo, Phillips Paul E, Middleton Frank A, Perl Andras
Abstract excerpt
OBJECTIVE: Endogenous retroviral sequences represent a link between viral and genetic factors that may influence the development of systemic lupus erythematosus (SLE). The HRES-1 human endogenous retroviral sequence is centrally located at the 1q42 chromosomal region relative to microsatellites previously associated with SLE. We therefore undertook the present study to determine the haplotypes of the HRES-1 locus...
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