Article
The Prognostic Role of β-Catenin Mutations in Desmoid-type Fibromatosis Undergoing Resection Only: A Meta-analysis of Individual Patient Data.
Annals of surgery - 1 Jun 2021
Timbergen Milea J M, Colombo Chiara, Renckens Michel, Kim Hee Sung, Rosmalen Joost van, Salas Sébastien, Mullen John T, Colombo Piergiuseppe, Nishida Yoshihiro, Wiemer Erik A C, Verhoef Cornelis, Sleijfer Stefan, Gronchi Alessandro, Grünhagen Dirk J
Abstract excerpt
OBJECTIVE: This meta-analysis (PROSPERO CRD42018100653) uses individual patient data (IPD) to assess the association between recurrence and CTNNB1 mutation status in surgically treated adult desmoid-type fibromatosis (DTF) patients. SUMMARY OF BACKGROUND DATA: The majority of sporadic DTF tumors harbor a CTNNB1 (ß-catenin) mutation: T41A, S45F, and S45P or are wild-type (WT). Results are conflicting regarding the...
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