Article
β-Catenin mutation status and outcomes in sporadic desmoid tumors.
The oncologist - 1 Jan 2013
Mullen John T, DeLaney Thomas F, Rosenberg Andrew E, Le Long, Iafrate A John, Kobayashi Wendy, Szymonifka Jackie, Yeap Beow Y, Chen Yen-Lin, Harmon David C, Choy Edwin, Yoon Sam S, Raskin Kevin A, Hornicek Francis J, Nielsen Gunnlauger P
Abstract excerpt
BACKGROUND: Mutations in the gene-encoding β-catenin, CTNNB1, are highly prevalent in sporadic desmoid tumors and may predict the risk for recurrence. We sought to determine the prevalence of CTNNB1 mutations in a large cohort of sporadic desmoid tumors and to determine whether CTNNB1 mutation status correlates with disease outcome. METHODS: Single-base extension genotyping of the CTNNB1 gene was performed on 145...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.