Article
Specific mutations in the beta-catenin gene (CTNNB1) correlate with local recurrence in sporadic desmoid tumors.
The American journal of pathology - 1 Nov 2008
Lazar Alexander J F, Tuvin Daniel, Hajibashi Shohrae, Habeeb Sultan, Bolshakov Svetlana, Mayordomo-Aranda Empar, Warneke Carla L, Lopez-Terrada Dolores, Pollock Raphael E, Lev Dina
Abstract excerpt
Desmoid fibromatosis is a rare, nonmetastatic neoplasm marked by local invasiveness and relentless recurrence. Molecular determinants of desmoid recurrence remain obscure. beta-Catenin deregulation has been commonly identified in sporadic desmoids although the incidence of CTNNB1 (the gene encoding beta-catenin) mutations is uncertain. Consequently, we evaluated the prevalence of CTNNB1 mutations in a large...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.