Article
CTNNB1 45F mutation is a molecular prognosticator of increased postoperative primary desmoid tumor recurrence: an independent, multicenter validation study.
Cancer - 15 Oct 2013
Colombo Chiara, Miceli Rosalba, Lazar Alexander J, Perrone Federica, Pollock Raphael E, Le Cesne Axel, Hartgrink Henk H, Cleton-Jansen Anne-Marie, Domont Julien, Bovée Judith V M G, Bonvalot Sylvie, Lev Dina, Gronchi Alessandro
Abstract excerpt
BACKGROUND: A role for the serine to phenylalanine substitution at codon 45 (the S45F mutation) in the catenin (cadherin-associated protein) β-1 (CTNNB1) gene as a molecular predictor of local recurrence in patients with primary, sporadic desmoid tumor (DT) has been reported. To confirm the previous data, the authors evaluated the correlation between CTNNB1 mutation type and local recurrence in this...
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