Article
An overview of neuroblastoma cell lineage phenotypes and in vitro models.
Experimental biology and medicine (Maywood, N.J.) - 1 Dec 2020
Campos Cogo Sheron, Gradowski Farias da Costa do Nascimento Thatyanne, de Almeida Brehm Pinhatti Fernanda, de França Junior Nilton, Santos Rodrigues Bruna, Cavalli Luciane Regina, Elifio-Esposito Selene
Abstract excerpt
This review was conducted to present the main neuroblastoma (NB) clinical characteristics and the most common genetic alterations present in these pediatric tumors, highlighting their impact in tumor cell aggressiveness behavior, including metastatic development and treatment resistance, and patients' prognosis. The distinct three NB cell lineage phenotypes, S-type, N-type, and I-type, which are characterized by...
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