Article
Clinical correlates of blood-derived circulating tumor DNA in pancreatic cancer.
Journal of hematology & oncology - 4 Dec 2019
Patel Hitendra, Okamura Ryosuke, Fanta Paul, Patel Charmi, Lanman Richard B, Raymond Victoria M, Kato Shumei, Kurzrock Razelle
Abstract excerpt
BACKGROUND: Treatment outcomes for patients with advanced pancreatic ductal adenocarcinoma (PDAC) remain dismal. There are unmet needs for understanding the biologic basis of this malignancy using novel next-generation sequencing technologies. Herein, we investigated the clinical utility of circulating tumor DNA (ctDNA) (the liquid biopsy) in this malignancy. METHODS: ctDNA was analyzed in 112 patients with PDAC...
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