Circulating Tumor DNA and Tissue Testing for Pancreatobiliary Tumors.

doi:10.1001/jamanetworkopen.2025.31373

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Circulating Tumor DNA and Tissue Testing for Pancreatobiliary Tumors.

JAMA network open - 2 Sept 2025

Mahadevia Himil, Majeed Umair, Patel Jaydeepbhai, Ahmed Ahmed K, Elhariri Ahmed, Albelal Douaa, Rao Nakka Naga Malleswara, Rachamala Hari Krishnareddy, Mosalem Osama, Mukhopadhyay Debabrata, Jones Jeremy, Mahadevan Daruka, Borad Mitesh J, Ahn Daniel, Sonbol Mohamad Bassam, Tran Nguyen, Mahipal Amit, Wee Ma Wen, McWilliams Robert R, Halfdanarson Thor R, Kankeu Fonkoua Lionel A, Bekaii-Saab Tanios, Mody Kabir, Babiker Hani

Abstract excerpt

Importance: The prognosis of advanced pancreaticobiliary tumors is poor. Next-generation sequencing (NGS) of tissue samples is utilized to identify actionable alterations, but there are occasional limitations due to inadequate tissue acquisition. Circulating tumor DNA (ctDNA) is an alternative method, but its correlation with tissue-based NGS remains unexplored. Objectives: To assess the mutation concordance...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Bile Duct Neoplasms

Share to Biomarkers, Tumor

Share to Carcinoma, Pancreatic Ductal

Share to Cholangiocarcinoma

Share to Circulating Tumor DNA

Share to High-Throughput Nucleotide Sequencing

Share to Pancreatic Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 40938601
DOI: 10.1001/jamanetworkopen.2025.31373
PMCID: PMC12432637

Genes

TP53
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Circulating Tumor DNA and Tissue Testing for Pancreatobiliary Tumors.PMID 40938601Read ↗

Prospective Evaluation of Circulating Tumor DNA Using Next-generation Sequencing as a Biomarker During Neoadjuvant Chemotherapy in Localized Pancreatic CancerSemantic proximity Read ↗

Clinical correlates of blood-derived circulating tumor DNA in pancreatic cancer.Semantic proximity Read ↗

Circulating tumor DNA: toward evolving the clinical paradigm of pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Detection of circulating tumor DNA without a tumor-informed search using next-generation sequencing is a prognostic biomarker in pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Molecular diagnosis of pancreatic and biliary cancer: ready for broad implementation?Semantic proximity Read ↗

Molecular diagnosis of pancreatobiliary tract cancer by detecting mutations and methylation changes in bile samplesSemantic proximity Read ↗

Validation and Clinical Utility of a Pan-Cancer Circulating Tumor DNA Assay as a First-Approach Test.Semantic proximity Read ↗

Next generation sequencing of pancreatic ductal adenocarcinoma: right or wrong?Semantic proximity Read ↗

Circulating Tumor DNA-Based Testing and Actionable Findings in Patients with Advanced and Metastatic Pancreatic Adenocarcinoma.Semantic proximity Read ↗

Prognostic impact of circulating tumor DNA detection in portal and peripheral blood in resected pancreatic ductal adenocarcinoma patients.Semantic proximity Read ↗

High-Sensitivity ctDNA Analysis Uncovers Relevant Signals Missed by NGS in Pancreatic Cancer.Semantic proximity Read ↗

Parallel Analysis of Pre- and Postoperative Circulating Tumor DNA and Matched Tumor Tissues in Resectable Pancreatic Ductal Adenocarcinoma: A Prospective Cohort Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.