Article
Utility of targeted deep sequencing for detecting circulating tumor DNA in pancreatic cancer patients.
Scientific reports - 2 Aug 2018
Park Gahee, Park Joo Kyung, Son Dae-Soon, Shin Seung-Ho, Kim Yeon Jeong, Jeon Hyo-Jeong, Lee Jae, Park Woong-Yang, Lee Kwang Hyuck, Park Donghyun
Abstract excerpt
Targeted deep sequencing across broad genomic regions has been used to detect circulating tumor DNA (ctDNA) in pancreatic ductal adenocarcinoma (PDAC) patients. However, since most PDACs harbor a mutation in KRAS, sequencing of broad regions needs to be systemically compared to analyzing only KRAS mutations for PDAC. Using capture-based targeted deep sequencing, we detected somatic tumor mutations in 17 fine...
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