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TGF-β inhibitor Smad7 regulates dendritic cell-induced autoimmunity

6 Feb 2017

Abstract excerpt

DCs in the spleen. Furthermore, Smad7-deficient DCs expressed higher levels of indoleamine 2,3-dioxygenase (IDO), an enzyme associated with tolerance induction. Mice devoid of Smad7 specifically in DCs are resistant to the development of experimental autoimmune encephalomyelitis (EAE) as a result of an increase of protective regulatory T cells (Tregs) and reduction of encephalitogenic effector T cells in the...

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PMID: 28167776
DOI: 10.1073/pnas.1615065114

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