MicroRNAs -122 and -1247 restrain the pathogenicity of effector CD4+ T cells in autoimmune inflammation

Abstract excerpt

<title>Abstract</title> <p>A hallmark of autoimmune diseases like multiple sclerosis (MS) is an imbalance between CD4⁺ T cell subsets, namely pro-inflammatory T helper 1 (Th)1 and Th17 cells, and anti-inflammatory Foxp3⁺ regulatory cells (Treg). Here we investigated which and how microRNAs (miRNAs) regulate these CD4⁺ T cell subsets in a pre-clinical model of MS. We established a...

Topics

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• Cytokine Signaling Pathways and Interactions
• Immune Cell Function and Interaction
• Immunotherapy and Immune Responses
• MicroRNA in disease regulation
• Multiple Sclerosis Research Studies
• Otitis Media and Relapsing Polychondritis
• Psoriasis: Treatment and Pathogenesis
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

7a522bf3-f333-5a42-9afb-66d902f6cb0a

DOI

10.21203/rs.3.rs-4187285/v1