Integrative analysis of spontaneous CLL regression highlights genetic and microenvironmental interdependency in CLL.

doi:10.1182/blood.2019001262

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Article

Integrative analysis of spontaneous CLL regression highlights genetic and microenvironmental interdependency in CLL.

Blood - 6 Feb 2020

Kwok Marwan, Oldreive Ceri, Rawstron Andy C, Goel Anshita, Papatzikas Grigorios, Jones Rhiannon E, Drennan Samantha, Agathanggelou Angelo, Sharma-Oates Archana, Evans Paul, Smith Edward, Dalal Surita, Mao Jingwen, Hollows Robert, Gordon Naheema, Hamada Mayumi, Davies Nicholas J, Parry Helen, Beggs Andrew D, Munir Talha, Moreton Paul, Paneesha Shankara, Pratt Guy, Taylor A Malcolm R, Forconi Francesco, Baird Duncan M, Cazier Jean-Baptiste, Moss Paul, Hillmen Peter, Stankovic Tatjana

Abstract excerpt

Spontaneous regression is a recognized phenomenon in chronic lymphocytic leukemia (CLL) but its biological basis remains unknown. We undertook a detailed investigation of the biological and clinical features of 20 spontaneous CLL regression cases incorporating phenotypic, functional, transcriptomic, and genomic studies at sequential time points. All spontaneously regressed tumors were IGHV-mutated with no...

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PMID: 31794600
DOI: 10.1182/blood.2019001262

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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