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Spontaneous regression of chronic lymphocytic leukemia: clinical and biologic features of 9 cases

22 Apr 2009

Abstract excerpt

In chronic lymphocytic leukemia (CLL), spontaneous regressions are an exceptional phenomenon, whose biologic features are unknown. We describe 9 CLL patients who underwent a spontaneous clinical regression over an 11-year follow-up, despite a residual neoplastic clone detected by flow cytometry. CD38 and ZAP-70 were negative in all cases. Immunoglobulin heavy chain variable region (IgVH) genes, mutated in all 7...

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PMID: 19387007
DOI: 10.1182/blood-2008-12-196568

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