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Article

Pathogenic germline variants among women with uterine cancer by ancestry: A commercial laboratory collaborative research registry study.

Gynecologic oncology - 1 Jun 2025

Johnson Caitlin R, Aryasomayajula Chinmayi, Francoeur Alex A, Stewart Chelsea, Sia Tiffany Y, Darcy Kathleen M, Tian Chunqiao, Kapp Daniel S, Liu Ying L, Chan John K

Abstract excerpt

OBJECTIVE: Uterine cancer (UC) is the most common gynecologic cancer in the United States, and 5-15 % of patients harbor a germline pathogenic variant (gPV) in a cancer predisposition gene. This study aims to characterize the germline landscape of patients with UC by self-identified ancestry. METHODS: Patients with UC who received germline testing were identified from the publicly available Myriad Collaborative...

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Identifiers

PMID: 40300426
DOI: 10.1016/j.ygyno.2025.04.585
PMCID: PMC12836400

Genes

BRCA1
MLH1
MSH2

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