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Article

Anxiolytic effects and neuroanatomical targets of estrogen receptor-β (ERβ) activation by a selective ERβ agonist in female mice.

Endocrinology - 1 Feb 2012

Oyola Mario G, Portillo Wendy, Reyna Andrea, Foradori Chad D, Kudwa Andrea, Hinds Laura, Handa Robert J, Mani Shaila K

Abstract excerpt

The dichotomous anxiogenic and anxiolytic properties of estrogens have been reported to be mediated by two distinct neural estrogen receptors (ER), ERα and ERβ, respectively. Using a combination of pharmacological and genetic approaches, we confirmed that the anxiolytic actions of estradiol are mediated by ERβ and extended and these observations to demonstrate the neuroanatomical targets involved in ERβ...

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Identifiers

PMID: 22186418
DOI: 10.1210/en.2011-1674
PMCID: PMC3275390

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CORT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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