Article

Collateral damage: Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme

2021-06-30

Abstract excerpt

Mice carrying targeted mutations are important for investigating gene function and the role of genes in disease, but the process of culturing embryonic stem cells during the making of a targeted allele offers opportunities for spontaneous mutations to arise. Identifying spontaneous mutations relies on the detection of phenotypes segregating independently of targeted alleles, and many phenotypes are easy to miss if...

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Literature Corpus work: 07dffb6a-0173-546e-9cad-b52cccd594d2
DOI: 10.1101/2021.06.30.450312

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