Article
Variable paralog expression underlies phenotype variation.
eLife - 22 Sept 2022
Bailon-Zambrano Raisa, Sucharov Juliana, Mumme-Monheit Abigail, Murry Matthew, Stenzel Amanda, Pulvino Anthony T, Mitchell Jennyfer M, Colborn Kathryn L, Nichols James T
Abstract excerpt
Human faces are variable; we look different from one another. Craniofacial disorders further increase facial variation. To understand craniofacial variation and how it can be buffered, we analyzed the zebrafish mef2ca mutant. When this transcription factor encoding gene is mutated, zebrafish develop dramatically variable craniofacial phenotypes. Years of selective breeding for low and high penetrance of mutant...
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