Article
SLCO1B1 Gene Variations Among Tanzanians, Ethiopians, and Europeans: Relevance for African and Worldwide Precision Medicine.
Omics : a journal of integrative biology - 1 Sept 2016
Aklillu Eleni, Habtewold Abiy, Ngaimisi Eliford, Yimer Getnet, Mugusi Sabina, Amogne Wondwossen, Reuter Tasmin, Meid Andreas, Hoffmann Michael Marcus, Weiss Johanna
Abstract excerpt
The solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene encodes for a membrane-bound organic anion transporter protein involved in active cellular influx of many endogenous compounds and xenobiotics. SLCO1B1 genetic variation is associated, for example, with highly variable rifampicin exposure, thus influencing the cornerstone antituberculosis therapy, especially in sub-Saharan Africa where...
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