Article
Genome-wide association study reveals two novel risk alleles for incident obstructive sleep apnea in the EPISONO cohort.
Sleep medicine - 1 Feb 2020
Farias Tempaku Priscila, Leite Santoro Marcos, Bittencourt Lia, D'Almeida Vania, Iole Belangero Sintia, Tufik Sergio
Abstract excerpt
OBJECTIVE/BACKGROUND: Obstructive sleep apnea (OSA) is a sleep-related breathing disorder that has a complex phenotype. Currently, few genes have been linked with OSA. Thus, the aim of this study was to conduct a genome-wide association study (GWAS) of the apnea-hypopnea index (AHI) variation along time (delta-AHI) in a prospective cohort. METHODS: We used data derived from the São Paulo Epidemiologic Sleep Study...
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