Article
A normal polymorphism site of TLR2 3' untranslated region is related to rheumatic heart disease by up-regulating TLR2 expression.
Annals of clinical biochemistry - 1 Jul 2015
Li Yanhua, Zhang Shu, Xu Wenhuan, Guo Xinhong, Xu Qiang, Chen Yundai
Abstract excerpt
BACKGROUND: The worldwide incidence of rheumatic heart disease is at least 15.6 million cases and is responsible for around 233,000 deaths per year. The pathogenesis of rheumatic heart disease is complex and involves genetic factors that predispose a person to the development of autoimmune reactions. Although Arg753Gln polymorphism of the TLR2 gene was considered to be related to acute rheumatic fever...
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