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Article

Beyond tumor mutation burden: tumor neoantigen burden as a superior prognostic biomarker in resected gastric cancer.

Frontiers in immunology - 1 Jan 2025

Lu Tingting, Cao Jingyi, Liu Peng, Pan Xiaoxin, Shen Yiming, Wang Jian, Chen Zhida, Liu Yi, Zhang Fenglin, Zhang Haiya, Zhang Gan, Wang Yi, Wan Ji, Xi Hongqing

Abstract excerpt

Introduction: Gastric cancer is one of the most diagnosed cancers and a major contributor to cancer-related death in China. Recent studies have demonstrated the failure of tumor mutational burden (TMB) in predictive accuracy. Here, we aimed to evaluate the prognostic value of tumor neoantigen burden (TNB) to predict the clinical outcome among patients undergoing gastric cancer resection. Methods: This study...

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Identifiers

PMID: 41562064
DOI: 10.3389/fimmu.2025.1722895
PMCID: PMC12813098

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