Performance of molecular inversion probe DR23K and Paragon MAD4HatTeR Amplicon sequencing panels for detection of Plasmodium falciparum mutations associated with antimalarial drug resistance.

doi:10.1186/s12936-025-05441-3

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Performance of molecular inversion probe DR23K and Paragon MAD4HatTeR Amplicon sequencing panels for detection of Plasmodium falciparum mutations associated with antimalarial drug resistance.

Malaria journal - 12 Jun 2025

Katairo Thomas, Asua Victor, Nsengimaana Bienvenu, Tukwasibwe Stephen, Semakuba Francis D, Wiringilimaana Innocent, Kagurusi Brian A, Mwubaha Caroline, Nakasaanya Jackie, Garg Shreeya, Kiyaga Shahiid, Mbabazi Monica, Kabbale Kisakye D, Ayitewala Alisen, Nsobya Samuel L, Kamya Moses R, Ssewanyana Isaac, Bailey Jeffrey A, Aranda-Díaz Andrés, Rosenthal Philip J, Greenhouse Bryan, Briggs Jessica, Conrad Melissa D

Abstract excerpt

BACKGROUND: Molecular surveillance of drug-resistant Plasmodium falciparum is crucial for malaria control in endemic regions. Two targeted-resequencing tools, the Molecular Inversion Probe (MIP) drug resistance panel DR23K and the Multiplexed Amplicons for Drugs, Diagnostics, Diversity, and Differentiation using High-Throughput Targeted Resequencing (MAD4HatTeR) panel, are widely used to detect resistance...

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PMID: 40506703
DOI: 10.1186/s12936-025-05441-3
PMCID: PMC12164144

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