Drug-resistant genotypes and multi-clonality in Plasmodium falciparum analysed by direct genome sequencing from peripheral blood of malaria patients.

doi:10.1371/journal.pone.0023204

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Article

Drug-resistant genotypes and multi-clonality in Plasmodium falciparum analysed by direct genome sequencing from peripheral blood of malaria patients.

PloS one - 1 Jan 2011

Robinson Timothy, Campino Susana G, Auburn Sarah, Assefa Samuel A, Polley Spencer D, Manske Magnus, MacInnis Bronwyn, Rockett Kirk A, Maslen Gareth L, Sanders Mandy, Quail Michael A, Chiodini Peter L, Kwiatkowski Dominic P, Clark Taane G, Sutherland Colin J

Abstract excerpt

Naturally acquired blood-stage infections of the malaria parasite Plasmodium falciparum typically harbour multiple haploid clones. The apparent number of clones observed in any single infection depends on the diversity of the polymorphic markers used for the analysis, and the relative abundance o...

Topics

Adult
Antigens, Protozoan
Base Sequence
Chromosomes
Clone Cells
Drug Resistance
Gene Dosage
Genes, Protozoan
Genetic Loci
Genome
Genome, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Haplotypes

High-Throughput Nucleotide Sequencing

Humans

Malaria

Middle Aged

Molecular Sequence Data

Plasmodium falciparum

Source

Open in PubMed Open full text

Identifiers

PMID: 21853089
DOI: 10.1371/journal.pone.0023204
PMCID: PMC3154926

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-21853089-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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