Sensitive and modular amplicon sequencing of Plasmodium falciparum diversity and resistance for research and public health.

doi:10.1038/s41598-025-94716-5

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Article

Sensitive and modular amplicon sequencing of Plasmodium falciparum diversity and resistance for research and public health.

Scientific reports - 28 Mar 2025

Aranda-Díaz Andrés, Neubauer Vickers Eric, Murie Kathryn, Palmer Brian, Hathaway Nicholas, Gerlovina Inna, Boene Simone, García-Ulloa Manuel, Cisteró Pau, Katairo Thomas, Semakuba Francis Ddumba, Nsengimaana Bienvenu, Gwarinda Hazel, García-Fernández Carla, Louie William, Esayas Endashaw, Da Silva Clemente, Datta Debayan, Kiyaga Shahiid, Wiringilimaana Innocent, Feleke Sindew Mekasha, Bennett Adam, Smith Jennifer L, Gadisa Endalamaw, Parr Jonathan B, Conrad Melissa D, Raman Jaishree, Tukwasibwe Stephen, Ssewanyana Isaac, Rovira-Vallbona Eduard, Tato Cristina M, Briggs Jessica, Mayor Alfredo, Greenhouse Bryan

Abstract excerpt

Targeted amplicon sequencing is a powerful and efficient tool for interrogating the Plasmodium falciparum genome, generating actionable data from infections to complement traditional malaria epidemiology. For maximum impact, genomic tools should be multi-purpose, robust, sensitive, and reproducible. We developed, characterized, and implemented MAD4HatTeR, an amplicon sequencing panel based on Multiplex Amplicons...

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Identifiers

PMID: 40155691
DOI: 10.1038/s41598-025-94716-5
PMCID: PMC11953298

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