Establishment of Patient-Derived Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumor Models for Predicting Therapeutic Response.

doi:10.1158/1078-0432.CCR-21-2092

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Article

Establishment of Patient-Derived Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumor Models for Predicting Therapeutic Response.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2022

Yebra Mayra, Bhargava Shruti, Kumar Avi, Burgoyne Adam M, Tang Chih-Min, Yoon Hyunho, Banerjee Sudeep, Aguilera Joseph, Cordes Thekla, Sheth Vipul, Noh Sangkyu, Ustoy Rowan, Li Sam, Advani Sunil J, Corless Christopher L, Heinrich Michael C, Kurzrock Razelle, Lippman Scott M, Fanta Paul T, Harismendy Olivier, Metallo Christian, Sicklick Jason K

Abstract excerpt

PURPOSE: Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the gastrointestinal tract, with mutant succinate dehydrogenase (SDH) subunits (A-D) comprising less than 7.5% (i.e., 150-200/year) of new cases annually in the United States. Contrary to GISTs harboring KIT or PDGFRA mutations, SDH-mutant GISTs affect adolescents/young adults, often metastasize, and are frequently resistant to tyrosine...

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Identifiers

PMID: 34426440
DOI: 10.1158/1078-0432.CCR-21-2092
PMCID: PMC8738129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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