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Article

Mucosal Antibodies: Defending Epithelial Barriers against HIV-1 Invasion

23 Nov 2019

Abstract excerpt

The power of mucosal anti-HIV-1 envelope immunoglobulins (Igs) to block virus transmission is underappreciated. We used passive immunization, a classical tool to unequivocally prove whether antibodies are protective. We mucosally instilled recombinant neutralizing monoclonal antibodies (nmAbs) of different Ig classes in rhesus macaques (RMs) followed by mucosal simian–human immunodeficiency virus (SHIV)...

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PMID: 31771162
DOI: 10.3390/vaccines7040194

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