Article
Single epitope mucosal vaccine delivered via immuno-stimulating complexes induces low level of immunity against simian-HIV.
Vaccine - 17 Nov 2006
Pahar Bapi, Cantu Mayra A, Zhao Wei, Kuroda Marcelo J, Veazey Ronald S, Montefiori David C, Clements John D, Aye Pyone P, Lackner Andrew A, Lovgren-Bengtsson Karin, Sestak Karol
Abstract excerpt
The difficulty in developing an effective vaccine to contain the HIV/AIDS epidemic coupled with the fact that primary HIV-1 infection typically occurs via mucosal sites has increased emphasis on vaccine approaches that protect at mucosal surfaces. In this study we employed HIV and simian-HIV (SHIV)-derived T helper (Th) and cytotoxic T lymphocyte (CTL) single epitopes incorporated into immuno-stimulating...
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