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Article

Relationships of Cerebrospinal Fluid Alzheimer's Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms.

Journal of Alzheimer's disease : JAD - 1 Jan 2020

Babić Leko Mirjana, Nikolac Perković Matea, Klepac Nataša, Švob Štrac Dubravka, Borovečki Fran, Pivac Nela, Hof Patrick R, Šimić Goran

Abstract excerpt

The noradrenergic and dopaminergic systems are affected in Alzheimer's disease (AD). Polymorphisms in genes encoding enzymes and proteins that are components of these systems can affect products of transcription and translation and lead to altered enzymatic activity and alterations in overall dopamine and noradrenaline levels. Catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAOB) are the enzymes that...

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Identifiers

PMID: 31771069
DOI: 10.3233/JAD-190991
PMCID: PMC7029364

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