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Article

Genotype-independent decrease in plasma dopamine beta-hydroxylase activity in Alzheimer's disease.

Progress in neuro-psychopharmacology & biological psychiatry - 1 Jul 2013

Mustapic Maja, Presecki Paola, Pivac Nela, Mimica Ninoslav, Hof Patrick R, Simic Goran, Folnegovic-Smalc Vera, Muck-Seler Dorotea

Abstract excerpt

The noradrenergic system is involved in the etiology and progression of Alzheimer's disease (AD) but its role is still unclear. Dopamine beta-hydroxylase (DBH) as a catecholamine-synthesizing enzyme plays a central role in noradrenaline (NA) synthesis and turnover. Plasma DBH (pDBH) activity shows wide inheritable interindividual variability that is under genetic control. The aim of this study was to determine...

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Source

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Identifiers

PMID: 23416088
DOI: 10.1016/j.pnpbp.2013.02.002
PMCID: PMC3952071

Genes

DBH

Variants

rs1611115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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