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Article

Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ε4 Allele in Alzheimer's Disease.

Current Alzheimer research - 1 Jan 2021

Babić Leko Mirjana, Nikolac Perković Matea, Nedić Erjavec Gordana, Klepac Nataša, Švob Štrac Dubravka, Borovečki Fran, Pivac Nela, Hof Patrick R, Šimić Goran

Abstract excerpt

BACKGROUND: The dopaminergic system is functionally compromised in Alzheimer's Disease (AD). The activity of Monoamine Oxidase B (MAOB), the enzyme involved in the degradation of dopamine, is increased during AD. Also, increased expression of MAOB occurs in the postmortem hippocampus and neocortex of patients with AD. The MAOB rs1799836 polymorphism modulates MAOB transcription, consequently influencing protein...

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PMID: 34533445
DOI: 10.2174/1567205018666210917162843

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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