Article
A Robust PCR Protocol for HIV Drug Resistance Testing on Low-Level Viremia Samples.
BioMed research international - 1 Jan 2017
Gupta Shivani, Taylor Tracy, Patterson Aileen, Liang Binhua, Bullard Jared, Sandstrom Paul, Van Domselaar Gary, Ji Hezhao
Abstract excerpt
The prevalence of drug resistance (DR) mutations in people with HIV-1 infection, particularly those with low-level viremia (LLV), supports the need to improve the sensitivity of amplification methods for HIV DR genotyping in order to optimize antiretroviral regimen and facilitate HIV-1 DR surveillance and relevant research. Here we report on a fully validated PCR-based protocol that achieves consistent...
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