Article
Nonsynonymous Mutations in Linker-2 of the Pdr5 Multidrug Transporter Identify a New RNA Stability Element.
G3 (Bethesda, Md.) - 7 Jan 2020
Rahman Hadiar, Rudrow Andrew, Carneglia Joshua, Joly Sister Stephen Patrick, Nicotera Dante, Naldrett Michael, Choy John, Ambudkar Suresh V, Golin John
Abstract excerpt
Analysis of synonymous mutations established that although the primary amino acid sequence remains unchanged, alterations in transcription and translation can result in significant phenotypic consequences. We report the novel observation that a series of nonsynonymous mutations in an unconserved stretch of amino acids found in the yeast multidrug efflux pump Pdr5 increases expression, thus enhancing multidrug...
Topics
- ATP-Binding Cassette Transporters
- Mutation
- RNA Stability
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins