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Article

Cancer-associated mutations in the ribosomal protein L5 gene dysregulate the HDM2/p53-mediated ribosome biogenesis checkpoint.

Oncogene - 1 Apr 2020

Oršolić Ines, Bursać Slađana, Jurada Deana, Drmić Hofman Irena, Dembić Zlatko, Bartek Jiri, Mihalek Ivana, Volarević Siniša

Abstract excerpt

Perturbations in ribosome biogenesis have been associated with cancer. Such aberrations activate p53 through the RPL5/RPL11/5S rRNA complex-mediated inhibition of HDM2. Studies using animal models have suggested that this signaling pathway might constitute an important anticancer barrier. To gain a deeper insight into this issue in humans, here we analyze somatic mutations in RPL5 and RPL11 coding regions,...

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Identifiers

PMID: 32108164
DOI: 10.1038/s41388-020-1231-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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