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Article

Dissection of major cancer gene variants in subsets of circulating tumor cells in advanced breast cancer.

Scientific reports - 21 Nov 2019

D'Oronzo Stella, Lovero Domenica, Palmirotta Raffaele, Stucci Luigia Stefania, Tucci Marco, Felici Claudia, Cascardi Eliano, Giardina Carmela, Cafforio Paola, Silvestris Franco

Abstract excerpt

Enumeration of circulating tumor cells (CTCs) may reflect the metastatic potential of breast cancer (BC). By using the DEPArray, we investigated CTCs with respect to their epithelial-to-mesenchymal transition phenotype and compared their genomic heterogeneity with tissue biopsies. Seventeen stage IV BC patients were enrolled. Pre-enriched CTC suspensions were stained with fluorescent-labeled antibodies to...

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Identifiers

PMID: 31754145
DOI: 10.1038/s41598-019-53660-x
PMCID: PMC6872745

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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