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Genomic Profiling of Isolated Circulating Tumor Cells from Metastatic Breast Cancer Patients

8 Nov 2012

Abstract excerpt

Molecular characterization of circulating tumor cells (CTC) from blood is technically challenging because cells are rare and difficult to isolate. We developed a novel approach to isolate CTCs from blood via immunomagnetic enrichment followed by fluorescence-activated cell sorting (IE-FACS). Isolated CTCs were subjected to genome-wide copy number analysis via array comparative genomic hybridization (aCGH). In...

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PMID: 23135909
DOI: 10.1158/0008-5472.can-11-3017

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