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Article

Systemic interindividual DNA methylation variants in cattle share major hallmarks with those in humans.

Genome biology - 15 Jul 2024

Chang Wen-Jou, Baker Maria S, Laritsky Eleonora, Gunasekara Chathura J, Maduranga Uditha, Galliou Justine C, McFadden Joseph W, Waltemyer Jessica R, Berggren-Thomas Bruce, Tate Brianna N, Zhang Hanxue, Rosen Benjamin D, Van Tassell Curtis P, Liu George E, Coarfa Cristian, Ren Yi Athena, Waterland Robert A

Abstract excerpt

BACKGROUND: We recently identified ~ 10,000 correlated regions of systemic interindividual epigenetic variation (CoRSIVs) in the human genome. These methylation variants are amenable to population studies, as DNA methylation measurements in blood provide information on epigenetic regulation throughout the body. Moreover, establishment of DNA methylation at human CoRSIVs is labile to periconceptional influences...

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PMID: 39004763
DOI: 10.1186/s13059-024-03307-6
PMCID: PMC11247883

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