Article
A multi-scale analysis of bull sperm methylome revealed both species peculiarities and conserved tissue-specific features.
BMC genomics - 29 May 2018
Perrier Jean-Philippe, Sellem Eli, Prézelin Audrey, Gasselin Maxime, Jouneau Luc, Piumi François, Al Adhami Hala, Weber Michaël, Fritz Sébastien, Boichard Didier, Le Danvic Chrystelle, Schibler Laurent, Jammes Hélène, Kiefer Hélène
Abstract excerpt
BACKGROUND: Spermatozoa have a remarkable epigenome in line with their degree of specialization, their unique nature and different requirements for successful fertilization. Accordingly, perturbations in the establishment of DNA methylation patterns during male germ cell differentiation have been associated with infertility in several species. While bull semen is widely used in artificial insemination, the...
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